ResMed AirSense 11 AutoSet
How to set up the ResMed AirSense 11 AutoSet
From the box to your first night. Keep the user guide that came with your machine nearby: if anything here differs from it, follow the guide.
Check the box
You should find the AirSense 11, a HumidAir 11 water tub, air tubing (ClimateLineAir 11 heated or SlimLine), the Air11 65W power supply and a travel bag. An SD card is included with some devices but not all.
If anything is cracked or missing, call the supplier who shipped it before your first night.
Put it on a level surface below your head
Set the machine on a stable, level surface such as a nightstand, lower than your head so any condensed water runs back toward the machine instead of into your mask.
Keep bedding and curtains away from the air inlet on the back.
Plug in the power
Connect the power cord into the power inlet at the back, connect the cord to the AC adaptor, then plug into the wall. Leave it plugged in: ResMed says this lets your care provider apply your prescription wirelessly if needed.
Do not plug a USB cable into the machine or the AC adaptor into a USB device; the guide warns this can damage both.
Attach the tubing
Push the air tubing firmly onto the outlet connector at the back of the machine. If you have ClimateLineAir 11 heated tubing, the end with the electrical connector goes on the machine, never on the mask.
Fill the water tub
Take the tub out of the machine before adding water. Use distilled water only in the HumidAir 11 Standard tub (white thumb grip), or drinking-quality water in the Cleanable tub (grey thumb grip).
Fill only to the maximum line (380 mL) with room temperature water, never hot water. Close the tub and slide it back into the side of the machine.
Connect your mask
Attach the free end of the tubing firmly to your assembled mask. Follow the mask's own user guide for fitting.
Complete the welcome screens
On first power-up, tap USER on the Welcome screen and follow the prompts. If your supplier says your prescription will be sent over the air, keep the machine where it has cellular signal (on the nightstand, not on the floor or in a drawer).
Pair myAir if you want it
The myAir app is optional. Install the latest version, open it, tap Continue and follow its Bluetooth pairing prompts; go to the MORE menu on the machine when the app asks. A Bluetooth symbol on the status bar confirms the link.
Check your mask fit
Put your mask on, then tap MORE and run Mask Fit. Adjust the cushion and headgear until the result shows a good seal.
Start your first night
Fit your mask and press the Start therapy/Standby button on top, or just breathe normally if SmartStart has been turned on. To stop, take the mask off and press the button, or wait a few seconds if SmartStop is on.
If you have chest pain, a severe headache or more breathlessness on therapy, contact your prescribing doctor.
After setup: settings worth knowing
- Ramp Time: Starts you at a low pressure and raises it to your prescribed pressure over the ramp period, so falling asleep feels easier. Auto (AutoRamp) holds the low pressure until the machine detects you are asleep.
- Pressure Relief (EPR): Lowers the pressure a little each time you breathe out (level 1, 2 or 3 cm H2O, never below 4 cm H2O) so exhaling against the air feels easier.
- Humidity Level: Sets how much moisture the heated humidifier adds. Turn it up for a dry nose or mouth, down if you get water in the mask.
- Climate Control: With ClimateLineAir 11 heated tubing and the water tub attached, Auto keeps the air at about 85% relative humidity and protects against rainout. Manual lets you set tube temperature and humidity separately, without guaranteed rainout protection.
- Tube Temperature: Sets the heated tube's temperature. Auto is 80 F (27 C); you can pick 60 to 86 F (16 to 30 C) or Off. Raising it is the first fix for droplets in the tube.
- Mask: Tells the machine which type of mask you use so it can account for it.
- Tube: Tells the machine which type of non-heated tubing is attached.
- SmartStart and SmartStop: SmartStart begins therapy when you breathe into the mask; SmartStop ends it a few seconds after you take the mask off.
- Run Warmup: Pre-heats the water in the tub before you start, so the first breaths are not cold or dry.
- Airplane Mode: Turns off wireless transmission for flights. Data will not send to your care provider while it is on.
Supplies that can help
Distilled water is what most CPAP humidifier chambers are meant to be filled with, because it leaves little or no mineral scale behind.
The air inlet filter keeps dust and lint out of the machine and your airway; it is a cheap part that needs regular replacement.
Tubing with a built-in heating wire that keeps humidified air warm all the way to the mask, which is the main fix for rainout (water droplets …
The plain hose between the machine and the mask; it wears out and should be replaced on a regular schedule.
The removable water tank of a CPAP humidifier; it wears and needs replacing, especially if it cracks, clouds or leaks.
A soft strap that supports the jaw to help keep the mouth closed, used mainly with nasal and nasal pillow masks to reduce mouth leaks.
A fabric sleeve that slips over CPAP tubing to insulate it, reduce condensation and make the hose feel softer against your skin.
A cord or converter that runs a CPAP from a 12 V or 24 V DC source, such as a car outlet, RV or deep cycle …
A battery pack that runs a CPAP machine without mains power, for camping, power outages or long flights.
A heat and moisture exchanger (HME) that captures warmth and moisture from your breath and returns it on the next breath, used mostly with travel CPAPs …
Plain, mild dish soap is the cleaning agent most CPAP makers and the FDA point to for masks, tubing and humidifier chambers.
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Sources
- nihstrokenet.uc.edu
- document.resmed.com
- resmed.com
- newsroom.resmed.com
- document.resmed.com
- cms.gov
- api.fda.gov
- sleepfiles.com
Last reviewed October 11, 2026. How we research · Report an error