ResMed AirSense 10 AutoSet
How to set up the ResMed AirSense 10 AutoSet
From the box to your first night. Keep the user guide that came with your machine nearby: if anything here differs from it, follow the guide.
Check the box
You should find the machine with its HumidAir humidifier, a water tub, air tubing, the power supply, a travel bag and usually an SD card already in its slot.
If you bought a used or refurbished unit, ask the seller how it was cleaned and replace the tubing, filter and tub before using it.
Set it on a level surface below your head
Use a stable, level spot such as a nightstand, lower than your head, so condensed water drains away from the mask. Do not tip the machine on its side with water in the tub.
Connect the power
Plug the power connector into the back of the machine, connect the cord to the power supply, then plug it into the wall. Leave it plugged in so it can send data to your care provider.
Attach the tubing
Push the air tubing firmly onto the air outlet at the back. With ClimateLineAir heated tubing, the electrical end goes on the machine, not the mask.
Fill the water tub
Open the tub and fill it with distilled water up to the maximum line. Do not use hot water and do not overfill.
Close the tub and slide it into the side of the machine until it is seated. The machine will not run on a plane or anywhere else without the tub (or a side cover) in place.
Connect your mask
Attach the free end of the tubing firmly to your assembled mask, following the mask's own user guide.
Check your mask setting and fit
From the Home screen, turn the dial to highlight My Options and press the dial. If Mask appears, set it to the type you use. Then highlight Run Mask Fit, press the dial, and adjust the cushion and headgear until you see a Good result.
Optional: warm the water first
In My Options, choose Run Warmup to pre-heat the water so the first air is not cold or dry.
Start therapy
Fit your mask and press Start/Stop, or just breathe normally if SmartStart is on. The current pressure shows in green; during ramp a circle spins until your prescribed pressure is reached.
If you get chest pain, a severe headache or more breathlessness, contact your prescribing doctor.
Read the Sleep Report in the morning
After you stop, the Sleep Report shows usage hours, mask seal and whether the humidifier worked. If the mask seal says it needs adjusting, rerun Mask Fit tonight. Repeated high event numbers are something to show your doctor.
After setup: settings worth knowing
- Ramp Time: Starts at a low pressure and climbs to your prescribed pressure. Auto holds low pressure until the machine detects sleep.
- Humidity Level: Sets how much moisture the humidifier adds. Turn it up for a dry nose or mouth, down for water in the mask.
- Climate Control: With ClimateLineAir heated tubing, Auto adjusts humidity and temperature for you; Manual lets you choose the humidity level yourself.
- Tube Temperature: Sets the heated tube temperature when you use ClimateLineAir tubing. Warmer tubing reduces droplets in the tube.
- Pressure Relief (EPR): Lowers pressure slightly as you breathe out so exhaling feels easier.
- SmartStart: Starts therapy when you breathe into the mask and stops it a few seconds after you take the mask off.
- Mask: Shows your mask type setting. Change it when you switch between mask types.
- Tube: Shows the tubing type when you are not using ClimateLineAir. Change it when you switch tubes.
- Run Warmup: Pre-heats the water before therapy so the air is not cold or dry at the start.
- Airplane Mode: Turns off wireless transmission for flights.
Supplies that can help
Distilled water is what most CPAP humidifier chambers are meant to be filled with, because it leaves little or no mineral scale behind.
The air inlet filter keeps dust and lint out of the machine and your airway; it is a cheap part that needs regular replacement.
Tubing with a built-in heating wire that keeps humidified air warm all the way to the mask, which is the main fix for rainout (water droplets …
The plain hose between the machine and the mask; it wears out and should be replaced on a regular schedule.
The removable water tank of a CPAP humidifier; it wears and needs replacing, especially if it cracks, clouds or leaks.
A soft strap that supports the jaw to help keep the mouth closed, used mainly with nasal and nasal pillow masks to reduce mouth leaks.
A fabric sleeve that slips over CPAP tubing to insulate it, reduce condensation and make the hose feel softer against your skin.
A cord or converter that runs a CPAP from a 12 V or 24 V DC source, such as a car outlet, RV or deep cycle …
A battery pack that runs a CPAP machine without mains power, for camping, power outages or long flights.
A padded bag that protects the machine, mask, tubing and power supply in transit.
Plain, mild dish soap is the cleaning agent most CPAP makers and the FDA point to for masks, tubing and humidifier chambers.
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Sources
- nihstrokenet.uc.edu
- document.resmed.com
- resmed.com
- investor.resmed.com
- newsroom.resmed.com
- shop.resmed.com
- cms.gov
- api.fda.gov
- sleepfiles.com
Last reviewed October 11, 2026. How we research · Report an error