Transcend 365 miniCPAP
How to set up the Transcend 365 miniCPAP
From the box to your first night. Keep the user guide that came with your machine nearby: if anything here differs from it, follow the guide.
Unpack and check the parts
Take everything out of the travel bag. You should have the 365 with its humidifier, the PSA3 power supply and power cords, the quick guide and a USB cable.
The air tube, the P10 battery and the mask are sold separately. If anything is missing or damaged, call the supplier that gave you the machine.
Let it reach room temperature
If the machine has been in a cold car or a hot trunk, let it sit in the bedroom for a while before you use it. The manual asks you to let it adjust to the room before therapy.
Fill the reservoir with distilled water
Unplug the machine first. Hold the reservoir on the table with one hand and lift the CPAP straight up off it with the other; the two halves are held together only by magnets.
Fill the reservoir over a sink with distilled water, or use the Transcend 365 water filter kit. Hold it upright and check that the water sits below the max fill line, which is the bottom of the reservoir seal.
Put the machine back on the reservoir
Line the heater cartridge on the bottom of the CPAP up with the opening in the reservoir and lower the CPAP onto it until the magnets snap together.
Go slowly so the reservoir seal does not fold over, because a folded seal leaks. If the seal ever comes loose, stop using the humidifier and call your dealer for a replacement.
Connect the tube and mask
Attach your mask to an air tube with a standard 22 mm connector. Push the other end of the tube fully onto the air outlet of the 365.
Plug in the power
Set the machine on a flat, stable surface lower than your head, not on the bed. Plug the power supply into the machine, then plug the power cord into the wall. The screen lights up with the home screen.
Keep the 365 at least 6 inches (15 cm) from a pacemaker, ICD or implanted neurostimulator, because the magnets that hold the reservoir may interfere with them.
Set your comfort options
Press Down and then Center to open the humidifier and choose a level from 0 to 10. Press Up and then Center to open Settings, where Therapy Settings holds Ramp and EZEX and Mask/Tube Settings lets you match your mask and tube.
Your pressure and therapy mode are set by your provider and are locked. If the pressure feels wrong, talk to your prescribing clinician.
Start your first night
Put your mask on, make sure nothing on the screen is highlighted, and press the Center button. If ramp is set up it starts on its own; once you reach full pressure you can press Down to ramp again.
The screen turns off after 30 seconds. Press any button to wake it.
In the morning, stop and dry
Press Center to stop therapy. Then start Drying Mode, which blows air for 30 minutes to clear moisture from the machine, tube and mask. The current manual says to hold the Up button for three seconds; an older 2018 quick guide says to hold Up and Down together, so follow the guide that matches your unit.
After setup: settings worth knowing
- Humidity level: Sets how much moisture the built-in humidifier adds, from 0 (off) to 10 (most).
- Ramp pressure: Sets the lower pressure that therapy starts at while you fall asleep. It cannot go above your starting pressure.
- Ramp time: Sets how long the machine takes to climb from ramp pressure to your prescribed pressure, from 0 to 45 minutes in 5 minute steps.
- Ramp restart: Drops the pressure back to the ramp level during the night if you wake up and want to fall asleep again at a lower pressure.
- EZEX pressure relief: Lowers pressure a little each time you breathe out. 0 is off and 3 gives the most relief.
- Mask and tube settings: Tells the machine which mask and tube you use so it can perform correctly with them.
- Drying Mode: Runs the blower for 30 minutes without therapy pressure to dry the humidifier, tube and mask. Do not sleep with it running, because it does not deliver your prescribed pressure.
Supplies that can help
Distilled water is what most CPAP humidifier chambers are meant to be filled with, because it leaves little or no mineral scale behind.
The air inlet filter keeps dust and lint out of the machine and your airway; it is a cheap part that needs regular replacement.
The plain hose between the machine and the mask; it wears out and should be replaced on a regular schedule.
A battery pack that runs a CPAP machine without mains power, for camping, power outages or long flights.
A padded bag that protects the machine, mask, tubing and power supply in transit.
A soft strap that supports the jaw to help keep the mouth closed, used mainly with nasal and nasal pillow masks to reduce mouth leaks.
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Sources
- mytranscend.com
- cdn.shopify.com
- thecpapshop.com
- cdn.shopify.com
- mytranscend.com
- mytranscend.com
- mytranscend.com
- sleepreviewmag.com
- cdn.shopify.com
- faa.gov
- gitlab.com
- sleepfiles.com
Last reviewed October 11, 2026. How we research · Report an error